A TNFR1–UBCH10 axis drives lung squamous cell carcinoma dedifferentiation and metastasis through a cell-autonomous signaling loop

A TNFR1–UBCH10 axis drives lung squamous cell carcinoma dedifferentiation and metastasis through a cell-autonomous signaling loop

Abstract Tumor necrosis factor receptor 1 (TNFR1), encoded by TNFRSF1A, is a critical transducer of inflammatory pathways, but its physiological role in human cancer is not completely understood. Here, we observed high expression of TNFR1 in many human lung squamous cell carcinoma (SCCs) samples and...

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Bibliographic Details
Main Authors: Zuoxiang Xiao, Gongping Shi, Sichuan Xi, Amit Kumar Singh, Jami Willette-Brown, Xin Li, Feng Zhu, Ling Su, Xiaolin Wu, David S. Schrump, Yinling Hu
Format: Article
Language:English
Published: Nature Publishing Group 2022-10-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-05308-4

Internet

https://doi.org/10.1038/s41419-022-05308-4

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