Effects of small molecule-induced dimerization on the programmed death ligand 1 protein life cycle

Effects of small molecule-induced dimerization on the programmed death ligand 1 protein life cycle

Abstract The programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1) checkpoint blockade is central to Immuno-Oncology based therapies, and alternatives to antibody blockers of this interaction are an active area of research due to antibody related toxicities. Recently, small molecule compounds...

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Bibliographic Details
Main Authors: Ilean Chai, Dmytro Kornyeyev, Edward Hsieh, Gesham Magombedze, Lance Stapleton, Magdeleine Hung, Hyock Joo Kwon, Erin Stefanutti, JeanPhilippe Belzile, Gregg Czerwieniec, Adele Y. Wang, Mariya Morar, Latesh Lad
Format: Article
Language:English
Published: Nature Portfolio 2022-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-25417-6

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https://doi.org/10.1038/s41598-022-25417-6

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