Genomic features of in vitro selected mutants of Escherichia coli with decreased susceptibility to tigecycline

Genomic features of in vitro selected mutants of Escherichia coli with decreased susceptibility to tigecycline

ABSTRACT: Objectives: The increase in multidrug-resistant bacteria has reached an alarming rate globally, making it necessary to understand the underlying mechanisms mediating resistance in order to discover new therapeutics. Tigecycline (TGC) is a last-resort antimicrobial agent for the treatment...

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Bibliographic Details
Main Authors: Mehri Haeili, Yalda Shoghi, Mohaddeseh Moghimi, Arash Ghodousi, Maryam Omrani, Daniela Maria Cirillo
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Journal of Global Antimicrobial Resistance
Subjects:
Tigecycline resistance
Escherichia coli
Efflux pumps
Fitness cost
Ribosomal protein
LPS inner core biosynthesis pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S2213716522001904

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http://www.sciencedirect.com/science/article/pii/S2213716522001904

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