Transcriptional and Epigenetic Consequences of DMSO Treatment on HepaRG Cells

Transcriptional and Epigenetic Consequences of DMSO Treatment on HepaRG Cells

Dimethyl sulfoxide (DMSO) is used to sustain or favor hepatocyte differentiation in vitro. Thus, DMSO is used in the differentiation protocol of the HepaRG cells that present the closest drug-metabolizing enzyme activities to primary human hepatocytes in culture. The aim of our study is to clarify i...

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Bibliographic Details
Main Authors: Hélène Dubois-Pot-Schneider, Caroline Aninat, Kathrin Kattler, Karim Fekir, Kathleen Jarnouen, Virginie Cerec, Denise Glaise, Abdulrahman Salhab, Gilles Gasparoni, Kubo Takashi, Seiichi Ishida, Jörn Walter, Anne Corlu
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Cells
Subjects:
DMSO
HepaRG cells
hepatic differentiation
gene expression
histone modification
Online Access:https://www.mdpi.com/2073-4409/11/15/2298

Internet

https://www.mdpi.com/2073-4409/11/15/2298

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