Monoclonal antibodies block transmission of genetically diverse Plasmodium falciparum strains to mosquitoes

Monoclonal antibodies block transmission of genetically diverse Plasmodium falciparum strains to mosquitoes

Abstract Malaria parasite transmission to mosquitoes relies on the uptake of sexual stage parasites during a blood meal and subsequent formation of oocysts on the mosquito midgut wall. Transmission-blocking vaccines (TBVs) and monoclonal antibodies (mAbs) target sexual stage antigens to interrupt hu...

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Bibliographic Details
Main Authors: Roos M. de Jong, Lisette Meerstein-Kessel, Dari F. Da, Sandrine Nsango, Joseph D. Challenger, Marga van de Vegte-Bolmer, Geert-Jan van Gemert, Elias Duarte, Noam Teyssier, Robert W. Sauerwein, Thomas S. Churcher, Roch K. Dabire, Isabelle Morlais, Emily Locke, Martijn A. Huynen, Teun Bousema, Matthijs M. Jore
Format: Article
Language:English
Published: Nature Portfolio 2021-08-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-021-00366-9

Internet

https://doi.org/10.1038/s41541-021-00366-9

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