Yap governs a lineage-specific neuregulin1 pathway-driven adaptive resistance to RAF kinase inhibitors

Yap governs a lineage-specific neuregulin1 pathway-driven adaptive resistance to RAF kinase inhibitors

Abstract Background Inactivation of the Hippo pathway promotes Yap nuclear translocation, enabling execution of a transcriptional program that induces tissue growth. Genetic lesions of Hippo intermediates only identify a minority of cancers with illegitimate YAP activation. Yap has been implicated i...

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Bibliographic Details
Main Authors: Maria E. R. Garcia-Rendueles, Gnana Krishnamoorthy, Mahesh Saqcena, Adrian Acuña-Ruiz, Giovanna Revilla, Elisa de Stanchina, Jeffrey A. Knauf, Rona Lester, Bin Xu, Ronald A. Ghossein, James A. Fagin
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Molecular Cancer
Subjects:
Hippo
YAP
BRAF
Thyroid cancer
HER2
HER3
Online Access:https://doi.org/10.1186/s12943-022-01676-9

Internet

https://doi.org/10.1186/s12943-022-01676-9

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