Accurate assignment of significance to neuropeptide identifications using Monte Carlo k-permuted decoy databases.

In support of accurate neuropeptide identification in mass spectrometry experiments, novel Monte Carlo permutation testing was used to compute significance values. Testing was based on k-permuted decoy databases, where k denotes the number of permutations. These databases were integrated with a rang...

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Bibliographic Details
Main Authors: Malik N Akhtar, Bruce R Southey, Per E Andrén, Jonathan V Sweedler, Sandra L Rodriguez-Zas
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4201571?pdf=render