CDK4/6 Inhibition Induces Senescence and Enhances Radiation Response by Disabling DNA Damage Repair in Oral Cavity Squamous Cell Carcinoma

CDK4/6 Inhibition Induces Senescence and Enhances Radiation Response by Disabling DNA Damage Repair in Oral Cavity Squamous Cell Carcinoma

Purpose: HPV(−) OCSCC resists radiation treatment. The <i>CDKN2A</i> gene, encoding p16INK4A, is commonly disrupted in OCSCC. p16 inhibits CDK4/CDK6, leading to cell cycle arrest, but the biological sequelae of CDK4/6 inhibition in OCSCC remains understudied. This study examines whether...

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Bibliographic Details
Main Authors: Nitisha Shrivastava, Claudia Gutierrez Chavez, Daniel Li, Vikas Mehta, Carlos Thomas, Cory D. Fulcher, Nicole Kawachi, Danielle M. Bottalico, Michael B. Prystowsky, Indranil Basu, Chandan Guha, Thomas J. Ow
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Cancers
Subjects:
head and neck squamous cell carcinoma (HNSCC)
oral cavity
organoids
PD-0332991 (palbociclib)
senescence
CDK4
Online Access:https://www.mdpi.com/2072-6694/15/7/2005

Internet

https://www.mdpi.com/2072-6694/15/7/2005

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