Enzyme-fusion strategies for redirecting and improving carotenoid synthesis in S. cerevisiae

Spatial clustering of enzymes has proven an elegant approach to optimize metabolite transfer between enzymes in synthetic metabolic pathways. Among the multiple methods used to promote colocalisation, enzyme fusion is probably the simplest. Inspired by natural systems, we have explored the metabolic...

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Bibliographic Details
Main Authors: Hery Rabeharindranto, Sara Castaño-Cerezo, Thomas Lautier, Luis F. Garcia-Alles, Christian Treitz, Andreas Tholey, Gilles Truan
Format: Article
Language:English
Published: Elsevier 2019-06-01
Series:Metabolic Engineering Communications
Online Access:http://www.sciencedirect.com/science/article/pii/S2214030118300178