PICALM::MLLT10 may indicate a new subgroup of acute leukemias with miscellaneous immunophenotype and poor initial treatment response but showing sensitivity to venetoclax

PICALM::MLLT10 may indicate a new subgroup of acute leukemias with miscellaneous immunophenotype and poor initial treatment response but showing sensitivity to venetoclax

Abstract The PICALM::MLLT10 fusion gene is a rare but recurrent event in acute leukemia (AL) associated with poor prognosis. It is still confused whether PICALM::MLLT10 can solely correspond to acute myeloid leukemia (AML) or acute lymphoblastic leukemia (ALL) or acute leukemias of ambiguous lineage...

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Bibliographic Details
Main Authors: Haimin Sun, Yongmei Zhu, Jianfeng Li, Lingling Zhao, Guang Yang, Zeying Yan, Sujiang Zhang
Format: Article
Language:English
Published: Wiley 2024-06-01
Series:eJHaem
Subjects:
acute leukemia
immunophenotyping
PICALM::MLLT10
venetoclax
Online Access:https://doi.org/10.1002/jha2.922

Internet

https://doi.org/10.1002/jha2.922

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