Neuroactive venom compounds obtained from Phlogiellus bundokalbo as potential leads for neurodegenerative diseases: insights on their acetylcholinesterase and beta-secretase inhibitory activities in vitro

Neuroactive venom compounds obtained from Phlogiellus bundokalbo as potential leads for neurodegenerative diseases: insights on their acetylcholinesterase and beta-secretase inhibitory activities in vitro

Abstract Background Spider venom is a rich cocktail of neuroactive compounds designed to prey capture and defense against predators that act on neuronal membrane proteins, in particular, acetylcholinesterases (AChE) that regulate synaptic transmission through acetylcholine (ACh) hydrolysis - an ex...

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Bibliographic Details
Main Authors: Simon Miguel M. Lopez, Jeremey S. Aguilar, Jerene Bashia B. Fernandez, Angelic Gayle J. Lao, Mitzi Rain R. Estrella, Mark Kevin P. Devanadera, Cydee Marie V. Ramones, Aaron Joseph L. Villaraza, Leonardo A. Guevarra Jr., Myla R. Santiago-Bautista, Librado A. Santiago
Format: Article
Language:English
Published: SciELO 2021-06-01
Series:Journal of Venomous Animals and Toxins including Tropical Diseases
Subjects:
Philippine spider venom
Spider venoms
Phlogiellus bundokalbo
Neurological diseases
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992021000100314&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992021000100314&tlng=en

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