Engineered extracellular vesicles efficiently deliver CRISPR-Cas9 ribonucleoprotein (RNP) to inhibit herpes simplex virus1 infection in vitro and in vivo

Engineered extracellular vesicles efficiently deliver CRISPR-Cas9 ribonucleoprotein (RNP) to inhibit herpes simplex virus1 infection in vitro and in vivo

Extracellular vesicles (EVs) have recently emerged as a promising delivery platform for CRISPR/Cas9 ribonucleoproteins (RNPs), owing to their ability to minimize off-target effects and immune responses. However, enhancements are required to boost the efficiency and safety of Cas9 RNP enrichment with...

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Bibliographic Details
Main Authors: Yuanda Wan, Liren Li, Ruilin Chen, Jiajia Han, Qiyun Lei, Zhipeng Chen, Xiaodong Tang, Wenyu Wu, Shuwen Liu, Xingang Yao
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Extracellular vesicles
CRISPR/Cas9
Ribonucleoproteins
PTGFRN
Fc/Spa
HSV1
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383523003878

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http://www.sciencedirect.com/science/article/pii/S2211383523003878

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