Ubiquitin-Specific Protease 25 Aggravates Acute Pancreatitis and Acute Pancreatitis-Related Multiple Organ Injury by Destroying Tight Junctions Through Activation of The STAT3 Pathway

Ubiquitin-Specific Protease 25 Aggravates Acute Pancreatitis and Acute Pancreatitis-Related Multiple Organ Injury by Destroying Tight Junctions Through Activation of The STAT3 Pathway

Ubiquitin-specific protease 25 (USP25) plays an important role in inflammation and immunity. However, the role of USP25 in acute pancreatitis (AP) is still unclear. To evaluate the role of USP25 in AP, we conducted research on clinical AP patients, USP25wild-type(WT)/USP25 knockout (USP25−/−) mice,...

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Bibliographic Details
Main Authors: Zhengru Liu, Mingming Qi, Shan Tian, Qian Yang, Jian Liu, Siwei Wang, Mengyao Ji, Rong Yu, Suqi Zeng, Jinting Li, Yuping Wei, Weiguo Dong
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
acute pancreatitis
ubiquitin-specific protease 25
multiple organ injury
tight junctions
signal transducer and activator of transcription 3 pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.806850/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.806850/full

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