Collateral responses to classical cytotoxic chemotherapies are heterogeneous and sensitivities are sparse

Abstract Chemotherapy resistance is a major obstacle to curing cancer patients. Combination drug regimens have shown promise as a method to overcome resistance; however, to date only some cancers have been cured with this method. Collateral sensitivity—the phenomenon whereby resistance to one drug i...

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Bibliographic Details
Main Authors: Simona Dalin, Beatrice Grauman-Boss, Douglas A. Lauffenburger, Michael T. Hemann
Format: Article
Language:English
Published: Nature Portfolio 2022-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-09319-1