Src Inhibitors Pyrazolo[3,4-d]pyrimidines, Si306 and Pro-Si306, Inhibit Focal Adhesion Kinase and Suppress Human Glioblastoma Invasion In Vitro and In Vivo

Src Inhibitors Pyrazolo[3,4-d]pyrimidines, Si306 and Pro-Si306, Inhibit Focal Adhesion Kinase and Suppress Human Glioblastoma Invasion In Vitro and In Vivo

Glioblastoma (GBM), as the most aggressive brain tumor, displays a high expression of Src tyrosine kinase, which is involved in the survival, migration, and invasiveness of tumor cells. Thus, Src emerged as a potential target for GBM therapy. The effects of Src inhibitors pyrazolo[3,4-<i>d<...

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Bibliographic Details
Main Authors: Marija Nešović, Aleksandra Divac Rankov, Ana Podolski-Renić, Igor Nikolić, Goran Tasić, Arianna Mancini, Silvia Schenone, Milica Pešić, Jelena Dinić
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Cancers
Subjects:
glioblastoma
Src tyrosine kinase inhibitor
cancer invasion
focal adhesion kinase
matrix metalloproteinase
Online Access:https://www.mdpi.com/2072-6694/12/6/1570

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https://www.mdpi.com/2072-6694/12/6/1570

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