PRDM9 activity depends on HELLS and promotes local 5-hydroxymethylcytosine enrichment

PRDM9 activity depends on HELLS and promotes local 5-hydroxymethylcytosine enrichment

Meiotic recombination starts with the formation of DNA double-strand breaks (DSBs) at specific genomic locations that correspond to PRDM9-binding sites. The molecular steps occurring from PRDM9 binding to DSB formation are unknown. Using proteomic approaches to find PRDM9 partners, we identified HEL...

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Bibliographic Details
Main Authors: Yukiko Imai, Mathilde Biot, Julie AJ Clément, Mariko Teragaki, Serge Urbach, Thomas Robert, Frédéric Baudat, Corinne Grey, Bernard de Massy
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-10-01
Series:eLife
Subjects:
PRDM9
HELLS
lsh
5hmC
recombination
meiosis
Online Access:https://elifesciences.org/articles/57117

Internet

https://elifesciences.org/articles/57117

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