CaMKIV mediates spine growth deficiency of hippocampal neurons by regulation of EGR3/BDNF signal axis in congenital hypothyroidism

CaMKIV mediates spine growth deficiency of hippocampal neurons by regulation of EGR3/BDNF signal axis in congenital hypothyroidism

Abstract Congenital hypothyroidism (CH) will cause cognitive impairment in the condition of delayed treatment. The hippocampus is one of the most affected tissues by CH, in which the functional structures of hippocampal neurons manifest deficiency due to aberrant expression of effector molecules. Th...

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Bibliographic Details
Main Authors: Hui Wu, Guihai Suo, Tianci Li, Yuqin Zheng, Haiying Li, Feifei Shen, Yongjun Wang, Haidong Ni, Youjia Wu
Format: Article
Language:English
Published: Nature Publishing Group 2022-12-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-022-01270-4

Internet

https://doi.org/10.1038/s41420-022-01270-4

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