HIV-1 Tat Activates Akt/mTORC1 Pathway and <i>AICDA</i> Expression by Downregulating Its Transcriptional Inhibitors in B Cells

HIV-1 Tat Activates Akt/mTORC1 Pathway and <i>AICDA</i> Expression by Downregulating Its Transcriptional Inhibitors in B Cells

HIV-1 infects T cells, but the most frequent AIDS-related lymphomas are of B-cell origin. Molecular mechanisms of HIV-1-induced oncogenic transformation of B cells remain largely unknown. HIV-1 Tat protein may participate in this process by penetrating and regulating gene expression in B cells. Both...

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Bibliographic Details
Main Authors: Burkitkan Akbay, Diego Germini, Amangeldy K. Bissenbaev, Yana R. Musinova, Evgeny V. Sheval, Yegor Vassetzky, Svetlana Dokudovskaya
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
HIV-1
Tat
Akt/mTORC1 pathway
AICDA
B cells
Online Access:https://www.mdpi.com/1422-0067/22/4/1588

Internet

https://www.mdpi.com/1422-0067/22/4/1588

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