6-Gingerol, a major ingredient of ginger, attenuated cisplatin-induced pica in rats via regulating 5-HT3R/Ca2+/CaMKII/ERK1/2 signaling pathway

6-Gingerol, a major ingredient of ginger, attenuated cisplatin-induced pica in rats via regulating 5-HT3R/Ca2+/CaMKII/ERK1/2 signaling pathway

6-gingerol, the representative single ingredient in ginger, was demonstrated antiemetic properties against CINV via blocking the 5-hydroxytryptamine 3 receptors (5-HT3Rs), however, its underlying mechanism has not been fully clarified. Emerging evidence suggested that the 5-HT3R-mediated activation...

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Bibliographic Details
Main Authors: Ziyao Mo, Yihong Xian, Ruifang Zhang, Yongzhao Dai, Weijian Chen, Ke Nie
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Journal of Functional Foods
Subjects:
6-gingerol
Cisplatin
Chemotherapy-induced nausea and vomiting
5-HT3R
Ca2+/CaMKII/ERK1/2 signaling
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464622004595

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http://www.sciencedirect.com/science/article/pii/S1756464622004595

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