A Selective Review of the Excitatory-Inhibitory Imbalance in Schizophrenia: Underlying Biology, Genetics, Microcircuits, and Symptoms

A Selective Review of the Excitatory-Inhibitory Imbalance in Schizophrenia: Underlying Biology, Genetics, Microcircuits, and Symptoms

Schizophrenia is a chronic disorder characterized by specific positive and negative primary symptoms, social behavior disturbances and cognitive deficits (e.g., impairment in working memory and cognitive flexibility). Mounting evidence suggests that altered excitability and inhibition at the molecul...

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Bibliographic Details
Main Authors: Yi Liu, Pan Ouyang, Yingjun Zheng, Lin Mi, Jingping Zhao, Yuping Ning, Wenbin Guo
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
schizophrenia
excitatory-inhibitory imbalance (E-I imbalance)
glutamate and gamma-aminobutyric acid (GABA) neurotransmissions
genetic models
microcircuits
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.664535/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.664535/full

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