A Selective Review of the Excitatory-Inhibitory Imbalance in Schizophrenia: Underlying Biology, Genetics, Microcircuits, and Symptoms

A Selective Review of the Excitatory-Inhibitory Imbalance in Schizophrenia: Underlying Biology, Genetics, Microcircuits, and Symptoms

Schizophrenia is a chronic disorder characterized by specific positive and negative primary symptoms, social behavior disturbances and cognitive deficits (e.g., impairment in working memory and cognitive flexibility). Mounting evidence suggests that altered excitability and inhibition at the molecul...

Full description

Bibliographic Details
Main Authors:	Yi Liu, Pan Ouyang, Yingjun Zheng, Lin Mi, Jingping Zhao, Yuping Ning, Wenbin Guo
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-10-01
Series:	Frontiers in Cell and Developmental Biology
Subjects:	schizophrenia excitatory-inhibitory imbalance (E-I imbalance) glutamate and gamma-aminobutyric acid (GABA) neurotransmissions genetic models microcircuits
Online Access:	https://www.frontiersin.org/articles/10.3389/fcell.2021.664535/full

Similar Items

Excitatory-inhibitory Imbalance and Autism Spectrum Disorder: Mechanism and Treatment Progress
by: SHI Yue, et al.
Published: (2023-07-01)

Integrated Excitatory/Inhibitory Imbalance and Transcriptomic Analysis Reveals the Association between Dysregulated Synaptic Genes and Anesthetic-Induced Cognitive Dysfunction
by: Yasheng Yan, et al.
Published: (2022-08-01)

Neurotransmitter-stimulated neuron-derived sEVs have opposite effects on amyloid β-induced neuronal damage
by: Yunxiao Dou, et al.
Published: (2021-10-01)

The electroretinogram b-wave amplitude: a differential physiological measure for Attention Deficit Hyperactivity Disorder and Autism Spectrum Disorder
by: Irene O. Lee, et al.
Published: (2022-05-01)

Role of cortical excitatory/inhibitory imbalance in autism spectrum disorders from a symptom severity trajectories framework: a study protocol
by: Laura Colomar, et al.
Published: (2023-03-01)

Cell-type-specific imaging of neurotransmission reveals a disrupted excitatory-inhibitory cortical network in isoflurane anaesthesia
by: Juan Guo, et al.
Published: (2021-03-01)

Imbalance of Excitation and Inhibition at Threshold Level In the Auditory Cortex
by: Yan eZhao, et al.
Published: (2015-03-01)

Association between Neuroligin-1 polymorphism and plasma glutamine levels in individuals with autism spectrum disorderResearch in context
by: In-Hee Lee, et al.
Published: (2023-09-01)

GABA, glutamate and excitatory-inhibitory ratios measured using short-TE STEAM MRS at 7-Tesla: Effects of macromolecule basis sets and baseline parameters
by: Tomohisa Okada, et al.
Published: (2023-07-01)

Epileptic Mechanisms Shared by Alzheimer’s Disease: Viewed via the Unique Lens of Genetic Epilepsy
by: Jing-Qiong Kang
Published: (2021-07-01)

TRIM32 Deficiency Impairs the Generation of Pyramidal Neurons in Developing Cerebral Cortex
by: Yan-Yun Sun, et al.
Published: (2022-01-01)

The contribution of inhibitory interneurons to circuit dysfunction in Fragile X Syndrome
by: Christian eCea-Del Rio, et al.
Published: (2014-08-01)

Loss of KCC2 in GABAergic Neurons Causes Seizures and an Imbalance of Cortical Interneurons
by: Kirill Zavalin, et al.
Published: (2022-03-01)

Excitatory GABA: How a correct observation may turn out to be an experimental artifact
by: Piotr eBregestovski, et al.
Published: (2012-04-01)

Excitatory and inhibitory responses in the brain to experimental pain: A systematic review of MR spectroscopy studies
by: Jessica Archibald, et al.
Published: (2020-07-01)

Pannexin-1 Modulates Inhibitory Transmission and Hippocampal Synaptic Plasticity
by: Francisca García-Rojas, et al.
Published: (2023-05-01)

Default activity patterns at the neocortical microcircuit level
by: Artur eLuczak, et al.
Published: (2012-06-01)

Shared and divergent principles of synaptic transmission between cortical excitatory neurons in rodent and human brain
by: Christiaan P. J. de Kock, et al.
Published: (2023-09-01)

Review of Research on Imbalance Problem in Deep Learning Applied to Object Detection
by: REN Ning, FU Yan, WU Yanxia, LIANG Pengju, HAN Xi
Published: (2022-09-01)

Loss-of-Function Models of the Metabotropic Glutamate Receptor Genes Grm8a and Grm8b Display Distinct Behavioral Phenotypes in Zebrafish Larvae (Danio rerio)
by: Teresa M. Lüffe, et al.
Published: (2022-06-01)

Generational synaptic functions of GABAA receptor β3 subunit deteriorations in an animal model of social deficit
by: Ming-Chia Chu, et al.
Published: (2022-07-01)

Commentary: GABA Depolarizes Immature Neurons and Inhibits Network Activity in the Neonatal Neocortex In vivo
by: Yuri eZilberter
Published: (2015-12-01)

Local Connection of Excitatory Neurons in Rat Motor-Associated Cortical Areas.
by: Takehsi eKaneko
Published: (2013-05-01)

Excitatory and inhibitory receptors utilize distinct post- and trans-synaptic mechanisms in vivo
by: Taisuke Miyazaki, et al.
Published: (2021-10-01)

The Fiscal Imbalances and Methodological Approaches to Their Assessment
by: Savchenko Yuliia M.
Published: (2021-06-01)

Glutamate and GABA in Microglia-Neuron Cross-Talk in Alzheimer’s Disease
by: Grzegorz A. Czapski, et al.
Published: (2021-10-01)

Influence of glutamatergic and GABAergic neurotransmission on obstructive sleep apnea
by: Piotr Kaczmarski, et al.
Published: (2023-07-01)

A Computational Study of Astrocytic GABA Release at the Glutamatergic Synapse: EAAT-2 and GAT-3 Coupled Dynamics
by: Bronac Flanagan, et al.
Published: (2021-07-01)

Molecular Pathology and Pharmacological Treatment of Autism Spectrum Disorder-Like Phenotypes Using Rodent Models
by: Hsiao-Ying Kuo, et al.
Published: (2018-11-01)

Transcranial Direct Current Stimulation in neurogenetic syndromes: new treatment perspectives for Down syndrome?
by: Alessio Faralli, et al.
Published: (2024-02-01)

Predicting migraine by two models effort reward imbalance and control-demand imbalance in job
by: Hamidreza Oreyzi, et al.
Published: (2017-03-01)

A paradoxical switch: the implications of excitatory GABAergic signaling in neurological disorders
by: Colin J. McArdle, et al.
Published: (2024-01-01)

Structural and functional dynamics of Excitatory Amino Acid Transporters (EAAT)
by: Thomas Rauen, et al.
Published: (2014-09-01)

PROSPECTS OF IMPLEMENTATION OF EUROPEAN PRACTICE OF FINANCIAL IMBALANCES REGULATION IN UKRAINE
by: L. P. Sidelnykova, et al.
Published: (2018-12-01)

Excitatory and Inhibitory Synaptic Imbalance Caused by Brain-Derived Neurotrophic Factor Deficits During Development in a Valproic Acid Mouse Model of Autism
by: Chuchu Qi, et al.
Published: (2022-04-01)

Neonatal ketamine exposure impairs infrapyramidal bundle pruning and causes lasting increase in excitatory synaptic transmission in hippocampal CA3 neurons
by: Omar Hoseá Cabrera, et al.
Published: (2022-12-01)

Reduced excitatory neurotransmission in the hippocampus after inflammation and sevoflurane anaesthesia
by: Shahin Khodaei, et al.
Published: (2023-06-01)

Impact of Energy Imbalance on Financial Rewards in Peer-to-Peer Electricity Markets
by: Timothy Capper, et al.
Published: (2022-01-01)

Mass and Aerodynamic Imbalance Estimates of Wind Turbines
by: Jenny Niebsch, et al.
Published: (2010-04-01)

The Role of Phospholipase C in GABAergic Inhibition and Its Relevance to Epilepsy
by: Hye Yun Kim, et al.
Published: (2021-03-01)