Discovery of an agonistic Siglec-6 antibody that inhibits and reduces human mast cells
An agonistic Siglec-6 antibody that binds to a membrane-distal domain of Siglec-6 is identified that induces inhibition and reduction of mast cells and suppresses anaphylaxis in a humanized mouse model.
Main Authors: | , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2022-11-01
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Series: | Communications Biology |
Online Access: | https://doi.org/10.1038/s42003-022-04207-w |