Discovery of an agonistic Siglec-6 antibody that inhibits and reduces human mast cells

Discovery of an agonistic Siglec-6 antibody that inhibits and reduces human mast cells

An agonistic Siglec-6 antibody that binds to a membrane-distal domain of Siglec-6 is identified that induces inhibition and reduction of mast cells and suppresses anaphylaxis in a humanized mouse model.

Bibliographic Details
Main Authors:	Julia Schanin, Wouter Korver, Emily C. Brock, John Leung, Zachary Benet, Thuy Luu, Katherine Chang, Alan Xu, Naomi De Freitas, Kenneth Luehrsen, Michael A. Brehm, Alan Wong, Bradford A. Youngblood
Format:	Article
Language:	English
Published:	Nature Portfolio 2022-11-01
Series:	Communications Biology
Online Access:	https://doi.org/10.1038/s42003-022-04207-w

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