Direct control of lysosomal catabolic activity by mTORC1 through regulation of V-ATPase assembly

Direct control of lysosomal catabolic activity by mTORC1 through regulation of V-ATPase assembly

mTORC1 blocks lysosomal nutrient generation. Here, the authors show that mTORC1 inactivation triggers V-ATPase assembly, which rapidly initiates lysosomal acidification and degradation of protein contents throughout the lysosomal population.

Bibliographic Details
Main Authors: Edoardo Ratto, S. Roy Chowdhury, Nora S. Siefert, Martin Schneider, Marten Wittmann, Dominic Helm, Wilhelm Palm
Format: Article
Language:English
Published: Nature Portfolio 2022-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-32515-6

Internet

https://doi.org/10.1038/s41467-022-32515-6

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