Nε-Carboxymethyl-Lysine Modification of Extracellular Matrix Proteins Augments Fibroblast Activation

Nε-Carboxymethyl-Lysine Modification of Extracellular Matrix Proteins Augments Fibroblast Activation

The extracellular matrix (ECM) is a dynamic complex protein network that provides structural integrity and plays an active role in shaping fibroblast behavior both in health and disease. Despite its essential functions, the impact of age-associated post-translational modifications on ECM-driven fibr...

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Bibliographic Details
Main Authors: Harshavardhana H. Ediga, Patrick Hester, Adithi Yepuri, Geereddy Bhanuprakash Reddy, Satish K. Madala
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:International Journal of Molecular Sciences
Subjects:
advanced glycation end products
Nε-carboxymethyl-lysine
extracellular matrix
myofibroblast transformation
idiopathic pulmonary fibrosis
Online Access:https://www.mdpi.com/1422-0067/24/21/15811

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https://www.mdpi.com/1422-0067/24/21/15811

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