Enhancement of Dissolving Capacity and Reducing Gastric Mucosa Irritation by Complex Formation of Resibufogenin with β-Cyclodextrin or 2-Hydroxypropyl-β-cyclodextrin

Enhancement of Dissolving Capacity and Reducing Gastric Mucosa Irritation by Complex Formation of Resibufogenin with β-Cyclodextrin or 2-Hydroxypropyl-β-cyclodextrin

Resibufogenin (RBG) is a natural medicinal ingredient with promising cardiac protection and antitumor activity. However, poor solubility and severe gastric mucosa irritation restrict its application in the pharmaceutical field. In this study, the inclusion complex of RBG with β-cyclodextrin (β-CD) a...

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Bibliographic Details
Main Authors: Nan Liu, Huan-Ping Chen, Zi-Meng Yang, Ming-Yu Xia, Dong Wang, Ling-He Zang, Dong-Chun Liu
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Molecules
Subjects:
resibufogenin
cyclodextrin
inclusion complex
dissolution rate
gastric mucosa irritation
Online Access:https://www.mdpi.com/1420-3049/27/10/3213

Internet

https://www.mdpi.com/1420-3049/27/10/3213

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