Synthesis of Pyrrolo[3,4-<i>b</i>]pyridin-5-ones via Ugi–Zhu Reaction and In Vitro–In Silico Studies against Breast Carcinoma

Synthesis of Pyrrolo[3,4-<i>b</i>]pyridin-5-ones via Ugi–Zhu Reaction and In Vitro–In Silico Studies against Breast Carcinoma

An Ugi–Zhu three-component reaction (UZ-3CR) coupled in a one-pot manner to a cascade process (<i>N</i>-acylation/<i>aza</i> Diels–Alder cycloaddition/decarboxylation/dehydration) was performed to synthesize a series of pyrrolo[3,4-<i>b</i>]pyridin-5-ones in 20% t...

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Bibliographic Details
Main Authors: Ivette Morales-Salazar, Carlos E. Garduño-Albino, Flora P. Montes-Enríquez, Dania A. Nava-Tapia, Napoleón Navarro-Tito, Leonardo David Herrera-Zúñiga, Eduardo González-Zamora, Alejandro Islas-Jácome
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Pharmaceuticals
Subjects:
breast cancer
docking
MCRs
Ugi–Zhu
Pyrrolo[3,4-<i>b</i>]pyridin-5-ones
MDA-MB-231
Online Access:https://www.mdpi.com/1424-8247/16/11/1562

Internet

https://www.mdpi.com/1424-8247/16/11/1562

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