Crystal structures reveal catalytic and regulatory mechanisms of the dual-specificity ubiquitin/FAT10 E1 enzyme Uba6

Crystal structures reveal catalytic and regulatory mechanisms of the dual-specificity ubiquitin/FAT10 E1 enzyme Uba6

Uba6 is an E1 enzyme that regulates numerous cellular processes by activating ubiquitin and FAT10 pathways. Here, the authors present crystal structures that illuminate Uba6 catalytic mechanisms and reveal inositol hexakisphosphate as a cofactor that modulates Uba6 activity.

Bibliographic Details
Main Authors: Lingmin Yuan, Fei Gao, Zongyang Lv, Digant Nayak, Anindita Nayak, Priscila dos Santos Bury, Kristin E. Cano, Lijia Jia, Natalia Oleinik, Firdevs Cansu Atilgan, Besim Ogretmen, Katelyn M. Williams, Christopher Davies, Farid El Oualid, Elizabeth V. Wasmuth, Shaun K. Olsen
Format: Article
Language:English
Published: Nature Portfolio 2022-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-32613-5

Internet

https://doi.org/10.1038/s41467-022-32613-5

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