IL12-mediated liver inflammation reduces the formation of AAV transcriptionally active forms but has no effect over preexisting AAV transgene expression.

IL12-mediated liver inflammation reduces the formation of AAV transcriptionally active forms but has no effect over preexisting AAV transgene expression.

Recombinant adenoassociated viral vectors (rAAV) have proven to be excellent candidates for gene therapy clinical applications. Recent results showed that cellular immunity to AAV represents a major challenge facing the clinical use of systemic administration of these vectors. Interestingly, no prec...

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Bibliographic Details
Main Authors: Irene Gil-Fariña, Marianna Di Scala, Lucia Vanrell, Cristina Olagüe, Africa Vales, Katherine A High, Jesus Prieto, Federico Mingozzi, Gloria Gonzalez-Aseguinolaza
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3699534?pdf=render

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http://europepmc.org/articles/PMC3699534?pdf=render

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