Topical Capsaicin in Poly(lactic-co-glycolic)acid (PLGA) Nanoparticles Decreases Acute Itch and Heat Pain

Topical Capsaicin in Poly(lactic-co-glycolic)acid (PLGA) Nanoparticles Decreases Acute Itch and Heat Pain

Background: Capsaicin, the hot pepper agent, produces burning followed by desensitization. To treat localized itch or pain with minimal burning, low capsaicin concentrations can be repeatedly applied. We hypothesized that alternatively controlled release of capsaicin from poly(lactic-co-glycolic aci...

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Bibliographic Details
Main Authors: Nathalie M. Malewicz, Zahra Rattray, Sebastian Oeck, Sebastian Jung, Vicente Escamilla-Rivera, Zeming Chen, Xiangjun Tang, Jiangbing Zhou, Robert H. LaMotte
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:International Journal of Molecular Sciences
Subjects:
capsaicin
nanoparticles
human
pruritogens
desensitization
itch
Online Access:https://www.mdpi.com/1422-0067/23/9/5275

Internet

https://www.mdpi.com/1422-0067/23/9/5275

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