Gut microbiota-derived lipid metabolites facilitate regulatory T cell differentiation

Abstract Commensal bacteria-derived metabolites are critical in regulating the host immune system. Although the impact of gut microbiota-derived hydrophilic metabolites, such as short-chain fatty acids, on immune cell functions and development has been well documented, the immunomodulatory effects o...

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Bibliographic Details
Main Authors: Hiroaki Shiratori, Hiroyuki Oguchi, Yosuke Isobe, Kyu-Ho Han, Akira Sen, Kyosuke Yakebe, Daisuke Takahashi, Michihiro Fukushima, Makoto Arita, Koji Hase
Format: Article
Language:English
Published: Nature Portfolio 2023-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-35097-5