Febuxostat ameliorates muscle degeneration and movement disorder of the dystrophin mutant model in Caenorhabditis elegans

Febuxostat ameliorates muscle degeneration and movement disorder of the dystrophin mutant model in Caenorhabditis elegans

Abstract Duchenne muscular dystrophy (DMD) is an inherited disorder with mutations in the dystrophin gene characterized by progressive muscle degeneration and weakness. Therapy such as administration of glucocorticoids, exon skipping of mutant genes and introduction of dystrophin mini-genes have bee...

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Bibliographic Details
Main Authors: Sawako Yoshina, Luna Izuhara, Rei Mashima, Yuka Maejima, Naoyuki Kamatani, Shohei Mitani
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Journal of Physiological Sciences
Subjects:
Caenorhabditis elegans
Dystrophin mutation
Febuxostat
Muscle degeneration
Movement disorder
Online Access:https://doi.org/10.1186/s12576-023-00888-y

Internet

https://doi.org/10.1186/s12576-023-00888-y

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