Interferon alpha induces a stronger antiviral effect than interferon lambda in HBV/HDV infected humanized mice

Interferon alpha induces a stronger antiviral effect than interferon lambda in HBV/HDV infected humanized mice

Recent studies indicate that treatment of chronic hepatitis D virus (HDV) with either pegylated interferon (IFN)λ or pegylated IFNα monotherapy leads to a dramatic decline in HDV RNA. Herein, we investigated the innate antiviral efficacy of IFNλ and IFNα in humanized mice that lack an adaptive immun...

Full description

Bibliographic Details
Main Authors: Sarah Duehren, Takuro Uchida, Masataka Tsuge, Nobuhiko Hiraga, Susan L. Uprichard, Ohad Etzion, Jeffrey Glenn, Christopher Koh, Theo Heller, Scott J. Cotler, Shiro Oka, Kazuaki Chayama, Harel Dahari
Format: Article
Language:English
Published: Elsevier 2024-11-01
Series:Virus Research
Subjects:
HBV DNA
HDV RNA
HBsAg
Human albumin
Humanized mice
Interferon alpha
Online Access:http://www.sciencedirect.com/science/article/pii/S0168170224001448

Internet

http://www.sciencedirect.com/science/article/pii/S0168170224001448

Similar Items