A Sox17 downstream gene Rasip1 is involved in the hematopoietic activity of intra-aortic hematopoietic clusters in the midgestation mouse embryo

A Sox17 downstream gene Rasip1 is involved in the hematopoietic activity of intra-aortic hematopoietic clusters in the midgestation mouse embryo

Abstract Background During mouse embryonic development, definitive hematopoiesis is first detected around embryonic day (E) 10.5 in the aorta-gonad-mesonephros (AGM) region. Hematopoietic stem cells (HSCs) arise in the dorsal aorta’s intra-aortic hematopoietic cell clusters (IAHCs). We have previous...

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Bibliographic Details
Main Authors: Gerel Melig, Ikuo Nobuhisa, Kiyoka Saito, Ryota Tsukahara, Ayumi Itabashi, Yoshiakira Kanai, Masami Kanai-Azuma, Mitsujiro Osawa, Motohiko Oshima, Atsushi Iwama, Tetsuya Taga
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Inflammation and Regeneration
Subjects:
Hematopoiesis
AGM
IAHC
HSC
Sox17
Rasip1
Online Access:https://doi.org/10.1186/s41232-023-00292-4

Internet

https://doi.org/10.1186/s41232-023-00292-4

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