GLCCI1 Deficiency Induces Glucocorticoid Resistance via the Competitive Binding of IRF1:GRIP1 and IRF3:GRIP1 in Asthma

GLCCI1 Deficiency Induces Glucocorticoid Resistance via the Competitive Binding of IRF1:GRIP1 and IRF3:GRIP1 in Asthma

GLCCI1 plays a significant role in modulating glucocorticoid (GC) sensitivity in asthma. This project determines the underlying mechanism that GLCCI1 deficiency attenuates GC sensitivity in dexamethasone (Dex)-treated Ovalbumin (OVA)-induced asthma mice and epithelial cells through upregulating bind...

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Bibliographic Details
Main Authors: Xinyue Hu, Shuanglinzi Deng, Lisha Luo, Yuanyuan Jiang, Huan Ge, Feifei Yin, Yingyu Zhang, Daimo Zhang, Xiaozhao Li, Juntao Feng
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Medicine
Subjects:
GLCCI1
glucocorticoid resistance
asthma
IRF1:GRIP1
IRF3:GRIP1
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2021.686493/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2021.686493/full

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