Intra-Peritoneal Administration of Mitochondrial DNA Provokes Acute Lung Injury and Systemic Inflammation via Toll-Like Receptor 9

Intra-Peritoneal Administration of Mitochondrial DNA Provokes Acute Lung Injury and Systemic Inflammation via Toll-Like Receptor 9

The pathogenesis of sepsis is complex. Mitochondrial dysfunction, which is responsible for energy metabolism, intrinsic apoptotic pathway, oxidative stress, and systemic inflammatory responses, is closely related with severe sepsis induced death. Mitochondria DNA (mtDNA) contain un-methylated cytosi...

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Bibliographic Details
Main Authors: Lemeng Zhang, Songyun Deng, Shuangping Zhao, Yuhang Ai, Lina Zhang, Pinhua Pan, Xiaoli Su, Hongyi Tan, Dongdong Wu
Format: Article
Language:English
Published: MDPI AG 2016-08-01
Series:International Journal of Molecular Sciences
Subjects:
lipopolysaccharide
mitochondrial DNA
acute lung injury
systemic inflammation
Online Access:http://www.mdpi.com/1422-0067/17/9/1425

Internet

http://www.mdpi.com/1422-0067/17/9/1425

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