Insulin receptor Arg717 and IGF-1 receptor Arg704 play a key role in ligand binding and in receptor activation

Insulin receptor Arg717 and IGF-1 receptor Arg704 play a key role in ligand binding and in receptor activation

The insulin receptor (IR, with its isoforms IR-A and IR-B) and the insulin-like growth factor 1 receptor (IGF-1R) are related tyrosine kinase receptors. Recently, the portfolio of solved hormone–receptor structures has grown extensively thanks to advancements in cryo-electron microscopy. However, th...

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Bibliographic Details
Main Authors: Anna Kertisová, Lenka Žáková, Kateřina Macháčková, Aleš Marek, Pavel Šácha, Petr Pompach, Jiří Jiráček, Irena Selicharová
Format: Article
Language:English
Published: The Royal Society 2023-11-01
Series:Open Biology
Subjects:
mutagenesis in vitro
peptide hormone
receptor modification
receptor tyrosine kinase
structure–function
Online Access:https://royalsocietypublishing.org/doi/10.1098/rsob.230142

Internet

https://royalsocietypublishing.org/doi/10.1098/rsob.230142

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