Transient SARS-CoV-2 RNA-Dependent RNA Polymerase Mutations after Remdesivir Treatment for Chronic COVID-19 in Two Transplant Recipients: Case Report and Intra-Host Viral Genomic Investigation

Transient SARS-CoV-2 RNA-Dependent RNA Polymerase Mutations after Remdesivir Treatment for Chronic COVID-19 in Two Transplant Recipients: Case Report and Intra-Host Viral Genomic Investigation

Remdesivir is the first FDA-approved drug for treating severe SARS-CoV-2 infection and targets RNA-dependent RNA polymerase (RdRp) that is required for viral replication. To monitor for the development of mutations that may result in remdesivir resistance during prolonged treatment, we sequenced SAR...

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Bibliographic Details
Main Authors: Shangxin Yang, Ashrit Multani, Jacob M. Garrigues, Michael S. Oh, Peera Hemarajata, Taylor Burleson, Nicole M. Green, Caspian Oliai, Pryce T. Gaynor, Omer E. Beaird, Drew J. Winston, Christopher S. Seet, Joanna M. Schaenman
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Microorganisms
Subjects:
SARS-CoV-2
Chronic COVID-19
RdRp
nsp3
nsp5
nsp7
Online Access:https://www.mdpi.com/2076-2607/11/8/2096

Internet

https://www.mdpi.com/2076-2607/11/8/2096

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