BCL-2 as therapeutic target for hematological malignancies

BCL-2 as therapeutic target for hematological malignancies

Abstract Disruption of the physiologic balance between cell proliferation and cell death is an important step of cancer development. Increased resistance to apoptosis is a key oncogenic mechanism in several hematological malignancies and, in many cases, especially in lymphoid neoplasias, has been at...

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Bibliographic Details
Main Authors: Guilherme Fleury Perini, Glaciano Nogueira Ribeiro, Jorge Vaz Pinto Neto, Laura Tojeiro Campos, Nelson Hamerschlak
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Journal of Hematology & Oncology
Subjects:
Apoptosis
Resistance
BCL-2
BH3-mimetics
Venetoclax
Leukemia
Online Access:http://link.springer.com/article/10.1186/s13045-018-0608-2

Internet

http://link.springer.com/article/10.1186/s13045-018-0608-2

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