Clonal gene signatures predict prognosis in mesothelioma and lung adenocarcinoma

Abstract Malignant pleural mesothelioma (MPM) is a rare but lethal pleural cancer with high intratumor heterogeneity (ITH). A recent study in lung adenocarcinoma has developed a clonal gene signature (ORACLE) from multiregional transcriptomic data and demonstrated high prognostic values and reproduc...

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Bibliographic Details
Main Authors: Yupei Lin, Bryan M. Burt, Hyun-Sung Lee, Thinh T. Nguyen, Hee-Jin Jang, Claire Lee, Wei Hong, Robert Taylor Ripley, Christopher I. Amos, Chao Cheng
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:npj Precision Oncology
Online Access:https://doi.org/10.1038/s41698-024-00531-y