Enhancer-promoter hubs organize transcriptional networks promoting oncogenesis and drug resistance

Abstract Recent advances in high-resolution mapping of spatial interactions among regulatory elements support the existence of complex topological assemblies of enhancers and promoters known as enhancer-promoter hubs or cliques. Yet, organization principles of these multi-interacting enhancer-promot...

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Bibliographic Details
Main Authors: Brent S. Perlman, Noah Burget, Yeqiao Zhou, Gregory W. Schwartz, Jelena Petrovic, Zora Modrusan, Robert B. Faryabi
Format: Article
Language:English
Published: Nature Portfolio 2024-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-52375-6