Bi-specific autoantigen-T cell engagers as targeted immunotherapy for autoreactive B cell depletion in autoimmune diseases

Bi-specific autoantigen-T cell engagers as targeted immunotherapy for autoreactive B cell depletion in autoimmune diseases

IntroductionIn autoimmune diseases, autoreactive B cells comprise only the 0.1-0.5% of total circulating B cells. However, current first-line treatments rely on non-specific and general suppression of the immune system, exposing patients to severe side effects. For this reason, identification of tar...

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Bibliographic Details
Main Authors: Luca Perico, Federica Casiraghi, Fabiane Sônego, Marta Todeschini, Daniela Corna, Domenico Cerullo, Anna Pezzotta, Patricia Isnard-Petit, Silvia Faravelli, Federico Forneris, Kader Thiam, Ariela Benigni, Giuseppe Remuzzi
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Immunology
Subjects:
autoimmune diseases
membranous nephropathy
anti-PLA2R antibodies
autoreactive B cell
targeted immunotherapies
bi-specific autoantigen-T cell engagers
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1335998/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1335998/full

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