Development and validation of an LC-MS/MS method to quantify ceftaroline in microdialysate samples from plasma and brain: Application to a preclinical pharmacokinetic investigation

Development and validation of an LC-MS/MS method to quantify ceftaroline in microdialysate samples from plasma and brain: Application to a preclinical pharmacokinetic investigation

A bioanalytical LC–MS/MS method was developed and validated to determine ceftaroline in microdialysate samples from plasma and brain. Ceftaroline was separated using a C18 column and a mobile phase consisting of water and acetonitrile, both with 5 mM of ammonium formate and acid formic 0.1%, eluted...

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Bibliographic Details
Main Authors: Victória Etges Helfer, Bruna Bernar Dias, Graziela de Araújo Lock, Caroline Andrade Tomaszewski, Lucas Suchecki Barnet, Fabiano Barreto, Alexandre Prehn Zavascki, Bibiana Verlindo de Araújo, Teresa Dalla Costa
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Heliyon
Subjects:
Ceftaroline
Microdialysis
LC-MS/MS
Unbound concentrations
Analytical method validation
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023037714

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http://www.sciencedirect.com/science/article/pii/S2405844023037714

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