EBV‐LMP1 induces APOBEC3s and mitochondrial DNA hypermutation in nasopharyngeal cancer

EBV‐LMP1 induces APOBEC3s and mitochondrial DNA hypermutation in nasopharyngeal cancer

Abstract An Epstein‐Barr virus (EBV)—encoded latent membrane protein 1 (LMP1) is a principal oncogene that plays a pivotal role in EBV‐associated malignant tumors including nasopharyngeal cancer (NPC). Recent genomic landscape studies revealed that NPC also contained many genomic mutations, suggesti...

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Bibliographic Details
Main Authors: Kousho Wakae, Satoru Kondo, Hai Thanh Pham, Naohiro Wakisaka, Lusheng Que, Yingfang Li, Xin Zheng, Kento Fukano, Kouichi Kitamura, Koichi Watashi, Hideki Aizaki, Takayoshi Ueno, Makiko Moriyama‐Kita, Kazuya Ishikawa, Yosuke Nakanishi, Kazuhira Endo, Masamichi Muramatsu, Tomokazu Yoshizaki
Format: Article
Language:English
Published: Wiley 2020-10-01
Series:Cancer Medicine
Subjects:
APOBEC
EBV‐LMP1
mitochondrial DNA
nasopharyngeal cancer
Online Access:https://doi.org/10.1002/cam4.3357

Internet

https://doi.org/10.1002/cam4.3357

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