Stress-induced Cdk5 activity enhances cytoprotective basal autophagy in Drosophila melanogaster by phosphorylating acinus at serine437

Stress-induced Cdk5 activity enhances cytoprotective basal autophagy in Drosophila melanogaster by phosphorylating acinus at serine437

Cdk5 is a post-mitotic kinase with complex roles in maintaining neuronal health. The various mechanisms by which Cdk5 inhibits and promotes neurodegeneration are still poorly understood. Here, we show that in Drosophila melanogaster Cdk5 regulates basal autophagy, a key mechanism suppressing neurode...

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Bibliographic Details
Main Authors: Nilay Nandi, Lauren K Tyra, Drew Stenesen, Helmut Krämer
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-12-01
Series:eLife
Subjects:
autophagy
neurodegeneration
Drosophila
compound eye
fat body
Online Access:https://elifesciences.org/articles/30760

Internet

https://elifesciences.org/articles/30760

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