Leiomodin-3-deficient mice display nemaline myopathy with fast-myofiber atrophy

Leiomodin-3-deficient mice display nemaline myopathy with fast-myofiber atrophy

Nemaline myopathy (NM) is one of the most common forms of congenital myopathy, and affects either fast myofibers, slow myofibers, or both. However, an animal model for congenital myopathy with fast-myofiber-specific atrophy is not available. Furthermore, mutations in the leiomodin-3 (LMOD3) gene hav...

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Bibliographic Details
Main Authors: Lei Tian, Sheng Ding, Yun You, Tong-ruei Li, Yan Liu, Xiaohui Wu, Ling Sun, Tian Xu
Format: Article
Language:English
Published: The Company of Biologists 2015-06-01
Series:Disease Models & Mechanisms
Subjects:
Leiomodin-3
Nemaline myopathy
Mouse
Fast-myofiber atrophy
Online Access:http://dmm.biologists.org/content/8/6/635

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