Structural characterization of the mitochondrial Ca2+ uniporter provides insights into Ca2+ uptake and regulation
Summary: The mitochondrial uniporter is a Ca2+-selective ion-conducting channel in the inner mitochondrial membrane that is involved in various cellular processes. The components of this uniporter, including the pore-forming membrane subunit MCU and the modulatory subunits MCUb, EMRE, MICU1, and MIC...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-08-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004221008634 |
| _version_ | 1819096375807180800 |
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| author | Wenping Wu Jimin Zheng Zongchao Jia |
| author_facet | Wenping Wu Jimin Zheng Zongchao Jia |
| author_sort | Wenping Wu |
| collection | DOAJ |
| description | Summary: The mitochondrial uniporter is a Ca2+-selective ion-conducting channel in the inner mitochondrial membrane that is involved in various cellular processes. The components of this uniporter, including the pore-forming membrane subunit MCU and the modulatory subunits MCUb, EMRE, MICU1, and MICU2, have been identified in recent years. Previously, extensive studies revealed various aspects of uniporter activities and proposed multiple regulatory models of mitochondrial Ca2+ uptake. Recently, the individual auxiliary components of the uniporter and its holocomplex have been structurally characterized, providing the first insight into the component structures and their spatial relationship within the context of the uniporter. Here, we review recent uniporter structural studies in an attempt to establish an architectural framework, elucidating the mechanism that governs mitochondrial Ca2+ uptake and regulation, and to address some apparent controversies. This information could facilitate further characterization of mitochondrial Ca2+ permeation and a better understanding of uniporter-related disease conditions. |
| first_indexed | 2024-12-21T23:58:12Z |
| format | Article |
| id | doaj.art-859abe3d0e014cd79c893b17df51a145 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-12-21T23:58:12Z |
| publishDate | 2021-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-859abe3d0e014cd79c893b17df51a1452022-12-21T18:45:46ZengElsevieriScience2589-00422021-08-01248102895Structural characterization of the mitochondrial Ca2+ uniporter provides insights into Ca2+ uptake and regulationWenping Wu0Jimin Zheng1Zongchao Jia2College of Chemistry, Beijing Normal University, Beijing 100875, China; School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang 311121, ChinaCollege of Chemistry, Beijing Normal University, Beijing 100875, China; Corresponding authorDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, ON K7L 3N6, Canada; Corresponding authorSummary: The mitochondrial uniporter is a Ca2+-selective ion-conducting channel in the inner mitochondrial membrane that is involved in various cellular processes. The components of this uniporter, including the pore-forming membrane subunit MCU and the modulatory subunits MCUb, EMRE, MICU1, and MICU2, have been identified in recent years. Previously, extensive studies revealed various aspects of uniporter activities and proposed multiple regulatory models of mitochondrial Ca2+ uptake. Recently, the individual auxiliary components of the uniporter and its holocomplex have been structurally characterized, providing the first insight into the component structures and their spatial relationship within the context of the uniporter. Here, we review recent uniporter structural studies in an attempt to establish an architectural framework, elucidating the mechanism that governs mitochondrial Ca2+ uptake and regulation, and to address some apparent controversies. This information could facilitate further characterization of mitochondrial Ca2+ permeation and a better understanding of uniporter-related disease conditions.http://www.sciencedirect.com/science/article/pii/S2589004221008634IonMolecular biologyMembranes |
| spellingShingle | Wenping Wu Jimin Zheng Zongchao Jia Structural characterization of the mitochondrial Ca2+ uniporter provides insights into Ca2+ uptake and regulation iScience Ion Molecular biology Membranes |
| title | Structural characterization of the mitochondrial Ca2+ uniporter provides insights into Ca2+ uptake and regulation |
| title_full | Structural characterization of the mitochondrial Ca2+ uniporter provides insights into Ca2+ uptake and regulation |
| title_fullStr | Structural characterization of the mitochondrial Ca2+ uniporter provides insights into Ca2+ uptake and regulation |
| title_full_unstemmed | Structural characterization of the mitochondrial Ca2+ uniporter provides insights into Ca2+ uptake and regulation |
| title_short | Structural characterization of the mitochondrial Ca2+ uniporter provides insights into Ca2+ uptake and regulation |
| title_sort | structural characterization of the mitochondrial ca2 uniporter provides insights into ca2 uptake and regulation |
| topic | Ion Molecular biology Membranes |
| url | http://www.sciencedirect.com/science/article/pii/S2589004221008634 |
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