Detection of NTRK fusions by RNA-based nCounter is a feasible diagnostic methodology in a real-world scenario for non-small cell lung cancer assessment

Detection of NTRK fusions by RNA-based nCounter is a feasible diagnostic methodology in a real-world scenario for non-small cell lung cancer assessment

Abstract NTRK1, 2, and 3 fusions are important therapeutic targets for NSCLC patients, but their prevalence in South American admixed populations needs to be better explored. NTRK fusion detection in small biopsies is a challenge, and distinct methodologies are used, such as RNA-based next-generatio...

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Main Authors: Rodrigo de Oliveira Cavagna, Edilene Santos de Andrade, Monise Tadin Reis, Flávia Escremim de Paula, Gustavo Noriz Berardinelli, Murilo Bonatelli, Gustavo Ramos Teixeira, Beatriz Garbe Zaniolo, Josiane Mourão Dias, Flávio Augusto Ferreira da Silva, Carlos Eduardo Baston Silva, Marina Xavier Reis, Erika Lopes Maia, Thainara Santos de Alencar, Alexandre Arthur Jacinto, Rachid Eduardo Noleto da Nóbrega Oliveira, Miguel A. Molina-Vila, Letícia Ferro Leal, Rui Manuel Reis
Format: Article
Language:English
Published: Nature Portfolio 2023-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-48613-4

Internet

https://doi.org/10.1038/s41598-023-48613-4

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