Novel molecular changes induced by Nrg1 hypomorphism and Nrg1-cannabinoid interaction in adolescence: a hippocampal proteomic study in mice.

Neuregulin 1 (NRG1) is linked to an increased risk of developing schizophrenia and cannabis dependence. Mice that are hypomorphic for Nrg1 (Nrg1 HET mice) display schizophrenia-relevant behavioural phenotypes and aberrant expression of serotonin and glutamate receptors. Nrg1 HET mice also display id...

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Bibliographic Details
Main Authors: Jarrah R Spencer, Keturah M.E. Darbyshire, Aurelie A. Boucher, Mohammed A. Kashem, Leonora E. Long, Iain S. McGregor, Tim eKarl, Jonathon Carl Arnold
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-02-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2013.00015/full