Mutations Conferring Increased Sensitivity to Tripartite Motif 22 Restriction Accumulated Progressively in the Nucleoprotein of Seasonal Influenza A (H1N1) Viruses between 1918 and 2009

Mutations Conferring Increased Sensitivity to Tripartite Motif 22 Restriction Accumulated Progressively in the Nucleoprotein of Seasonal Influenza A (H1N1) Viruses between 1918 and 2009

ABSTRACT Influenza A viruses (IAVs) can cause zoonotic infections with pandemic potential when most of the human population is immunologically naive. After a pandemic, IAVs evolve to become seasonal in the human host by acquiring adaptive mutations. We have previously reported that the interferon (I...

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Bibliographic Details
Main Authors: Isabel Pagani, Andrea Di Pietro, Alexandra Oteiza, Michela Ghitti, Nadir Mechti, Nadia Naffakh, Elisa Vicenzi
Format: Article
Language:English
Published: American Society for Microbiology 2018-04-01
Series:mSphere
Subjects:
influenza A virus
TRIM22
evolution
nucleoprotein
restriction
Online Access:https://journals.asm.org/doi/10.1128/mSphere.00110-18

Internet

https://journals.asm.org/doi/10.1128/mSphere.00110-18

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